Abstract #2355
Comparison of PASL, pCASL and background suppressed 3D pCASL in a Clinical Population
Sudipto Dolui 1,2 , Marta Vidorreta 1 , Ze Wang 3,4 , David A. Wolk 1 , and John A. Detre 1,2
1
Department of Neurology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Department
of Radiology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States,
3
Hangzhou
Normal University, Hangzhou, Zhejiang, China,
4
Department
of Psychiatry and Radiology, University of Pennsylvania,
Pennsylvania, United States
We compared ASL MRI acquired from MCI patients and
elderly control subjects using PASL and pCASL 2D EPI and
pCASL background suppressed (BS) 3D spiral imaging. The
methods demonstrate strong correlations between mean
CBFs in different ROIs with strongest correlation
between measures obtained using either same labeling
(pCASL) or imaging strategy (2D). Temporal SNR of 3D BS
is higher than the other approaches although its GM-WM
contrast is lower than 2D pCASL. Observed
control>patient differences in PCC CBF increased with
the use of pCASL BS 3D vs pCASL non BS 2D and were not
evident in PASL data.
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