Meeting Banner
Abstract #2355

Comparison of PASL, pCASL and background suppressed 3D pCASL in a Clinical Population

Sudipto Dolui 1,2 , Marta Vidorreta 1 , Ze Wang 3,4 , David A. Wolk 1 , and John A. Detre 1,2

1 Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3 Hangzhou Normal University, Hangzhou, Zhejiang, China, 4 Department of Psychiatry and Radiology, University of Pennsylvania, Pennsylvania, United States

We compared ASL MRI acquired from MCI patients and elderly control subjects using PASL and pCASL 2D EPI and pCASL background suppressed (BS) 3D spiral imaging. The methods demonstrate strong correlations between mean CBFs in different ROIs with strongest correlation between measures obtained using either same labeling (pCASL) or imaging strategy (2D). Temporal SNR of 3D BS is higher than the other approaches although its GM-WM contrast is lower than 2D pCASL. Observed control>patient differences in PCC CBF increased with the use of pCASL BS 3D vs pCASL non BS 2D and were not evident in PASL data.

This abstract and the presentation materials are available to members only; a login is required.

Join Here