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Abstract #2359

Application of pseudo-continuous arterial spin labeling for quantification of hepatic perfusion

Mike-Ely Cohen 1,2 , Isabelle Lajoie 2 , Kenneth Dyson 2 , Olivier Lucidarme 1,3 , Richard D. Hoge 2,4 , and Frdrique Frouin 1,5

1 Laboratoire d'imagerie biomedicale, Sorbonne Universit Univ Paris 06, Inserm, CNRS, Paris, France, 2 Centre de recherche de linstitut universitaire de griatrie de Montral, Montral, Quebec, Canada, 3 Service de Radiologie Polyvalente Diagnostique et Oncologique, CHU Piti-Salptrire, AP-HP, Paris, France, 4 McConnell Brain Imaging Centre, Montreal Neurological Institute - McGill University, Quebec, Canada, 5 CEA/I2BM/SHFJ, IMIV, Orsay, France

The purpose of this study was to optimize a pseudo-Continuous Arterial Spin Labeling (pCASL) approach to quantify hepatic perfusion among healthy volunteers. Six volunteers were examined using a 3T Siemens scanner, pCASL sequences with 4 to 20 measurements in a plane orthogonal to portal vein with a post label delay (PLD) of 600 ms were acquired. For two subjects, four additional PLD (from 1000 to 1600 ms) were tested. Results show a more robust estimation when using 20 measurements. Furthermore the five PLD values provided hepatic perfusion weighted differently by the hepatic artery and the portal vein blood flows.

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