Effect of long-duration isoflurane administration on regional cerebral blood flow
Chun-Xia Li 1 , Sudeep Patel 1 , and Xiaodong Zhang 1
Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA,
Isoflurane is popularly used for long-duration
anesthesia in clinic practice or preclinical researches.
It is known that long-duration anesthesia could cause
neurocognitive dysfunction in animal and human. However,
the potential mechanism remains unclear. In the present
study, the pseudo continuous arterial-spin-labeling
(pCASL) technique was used to evaluate the isoflurane
anesthesia effect on cerebral blood flow (CBF) of adult
rhesus monkeys under maintenance dosage for 4 hours. The
results demonstrate that long-duration isoflurane
exposure could cause general CBF decrease in most brain
areas, which may contribute to the neurocognitive
dysfunction observed in clinical or preclinical studies.
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