Meeting Banner
Abstract #2364

Effect of long-duration isoflurane administration on regional cerebral blood flow

Chun-Xia Li 1 , Sudeep Patel 1 , and Xiaodong Zhang 1

1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

Isoflurane is popularly used for long-duration anesthesia in clinic practice or preclinical researches. It is known that long-duration anesthesia could cause neurocognitive dysfunction in animal and human. However, the potential mechanism remains unclear. In the present study, the pseudo continuous arterial-spin-labeling (pCASL) technique was used to evaluate the isoflurane anesthesia effect on cerebral blood flow (CBF) of adult rhesus monkeys under maintenance dosage for 4 hours. The results demonstrate that long-duration isoflurane exposure could cause general CBF decrease in most brain areas, which may contribute to the neurocognitive dysfunction observed in clinical or preclinical studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here