Effect of long-duration isoflurane administration on regional cerebral blood flow

Isoflurane is popularly used for long-duration anesthesia in clinic practice or preclinical researches. It is known that long-duration anesthesia could cause neurocognitive dysfunction in animal and human. However, the potential mechanism remains unclear. In the present study, the pseudo continuous arterial-spin-labeling (pCASL) technique was used to evaluate the isoflurane anesthesia effect on cerebral blood flow (CBF) of adult rhesus monkeys under maintenance dosage for 4 hours. The results demonstrate that long-duration isoflurane exposure could cause general CBF decrease in most brain areas, which may contribute to the neurocognitive dysfunction observed in clinical or preclinical studies.

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