Effect of ketamine and isoflurane anesthesia on regional cerebral blood flow of macaque monkeys

Ketamine and isoflurane are widely used for maintaining general anesthesia and induce a global CBF increase in humans and animals. However, it is not clear how differently the CBF is affected between the anesthetics. In the present study, adult rhesus monkeys were used to examine the effects of ketamine and isoflurane on CBF using the continuous arterial spin-labeling (CASL) perfusion MRI. The present study revealed the different effects of ketamine and isoflurane on CBF in monkeys under maintenance doses, suggesting the use of ketamine or isoflurane might interfere with the experimental outcome in neurovascular diseases and brain function studies.

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