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Abstract #2362

Dual temporal resolution DCE-MRI reveals increased blood-brain barrier leakage in cerebral small vessel disease

Sau May Wong 1 , Eleana Zhang 2 , Harm J. van de Haar 1 , Julie E.A. Staals 2 , Ccile R.L.P.N. Jeukens 1 , Paul A.M. Hofman 1 , Robert J. van Oostenbrugge 2 , Jacobus F.A. Jansen 1 , and Walter H. Backes 1

1 Radiology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands, 2 Neurology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands

Cerebral small vessel disease(cSVD) affects the small vessels in the brain, which can potentially lead to ischemic stroke and dementia. The blood-brain barrier (BBB) permeability is expected to play a pivotal role in the pathophysiology. We performed dual temporal resolution DCE-MRI to quantify BBB permeability. Significant higher permeability was found for cSVD patients compared with controls in the normal appearing brain tissue, which suggests that these regions might be at risk for further transition into white matter hyperintensities. Longitudinal studies can now be initiated to investigate the role of increased BBB permeability in the course of cSVD.

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