Whole Brain Measurement of Dynamics of Arterial Spin Labeling Using Multi-Band Look-Locker Technique in Hypertension

The dynamics of the arterial spin labeling (ASL) provides information on the kinetics of water exchange between tissue and blood, transit time, and the tissue relaxation time. In this study, multi-band technique was applied to look-locker ASL to get the perfusion dynamics for whole brain with a sufficient temporal resolution. We found the hypertensive group has significantly longer capillary transit time and maximal arterial arrival time in most ROIs, while the arterial transit time was not significantly different, compared to the normotensive group. We demonstrated that our technique enables the detection of regional hypertension-induced cerebrovascular impairment in whole brain.

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