Whole Brain Measurement of Dynamics of Arterial Spin Labeling Using Multi-Band Look-Locker Technique in Hypertension
Yoojin Lee 1 and Tae Kim 1
Department of Radiology, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States
The dynamics of the arterial spin labeling (ASL)
provides information on the kinetics of water exchange
between tissue and blood, transit time, and the tissue
relaxation time. In this study, multi-band technique was
applied to look-locker ASL to get the perfusion dynamics
for whole brain with a sufficient temporal resolution.
We found the hypertensive group has significantly longer
capillary transit time and maximal arterial arrival time
in most ROIs, while the arterial transit time was not
significantly different, compared to the normotensive
group. We demonstrated that our technique enables the
detection of regional hypertension-induced
cerebrovascular impairment in whole brain.
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