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Abstract #2524

Three dimensional three parameter direct inversion MR elastography of incompressible transverse isotropic media: Application to in vivo soleus muscle

Jing Guo 1 , Sebastian Hirsch 1 , Jrgen Braun 2 , and Ingolf Sack 3

1 Radiology, Charit - Universittsmedizin Berlin, Berlin, Berlin, Germany, 2 Department of Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Germany, 3 Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany

An anisotropic MR elastography method is introduced which relies on shear fields in incompressible transversely-isotropic media. The method provides three independent moduli, μ 12 , μ 13 and E 3 , the shear moduli in the planes of isotropy and symmetry as well as the Young's modulus parallel to the fiber axis, respectively. The method is demonstrated on the soleus in ten healthy volunteers and reveals that 1) E 3 > μ 13 > μ 12 and 2) elasticity parameters along the muscle fiber axis are higher in the right leg compared to the left leg which is most likely resulting from the right leg dominance of soleus function in our group.

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