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Abstract #2525

The Accuracy of Multi-Slice Multi-Frequency MR Elastography in a Brain Stiffness Mimicking Phantom

Arvin Arani 1 , Ondrej Slezak 1 , Nikoo Fattahi 1 , Kevin J Glaser 1 , Joel Felmlee 1 , Armando Manduca 2 , Clifford R. Jack 1 , Richard L. Ehman 1 , and John Huston III 1

1 Radiology, Mayo Clinic, Rochester, Minnesota, United States, 2 Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States

Several groups have investigated the use of MR elastography in neurological diseases, using a single vibration frequency or the use of multi-frequency data to acquire information about the viscoelastic properties of brain tissues. Although the precision, repeatability, and sensitivity to changes in these viscoelastic parameters has been reported in phantoms and in vivo, the accuracy of either the single-frequency or multi-frequency stiffness measurements has not been thoroughly evaluated experimentally. The objective of this work was to evaluate the accuracy of both single-frequency and multi-frequency brain MRE in a geometrically accurate brain stiffness mimicking phantom and compare it with mechanical testing.

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