Abstract #2525
The Accuracy of Multi-Slice Multi-Frequency MR Elastography in a Brain Stiffness Mimicking Phantom
Arvin Arani 1 , Ondrej Slezak 1 , Nikoo Fattahi 1 , Kevin J Glaser 1 , Joel Felmlee 1 , Armando Manduca 2 , Clifford R. Jack 1 , Richard L. Ehman 1 , and John Huston III 1
1
Radiology, Mayo Clinic, Rochester,
Minnesota, United States,
2
Physiology
and Biomedical Engineering, Mayo Clinic, Rochester,
Minnesota, United States
Several groups have investigated the use of MR
elastography in neurological diseases, using a single
vibration frequency or the use of multi-frequency data
to acquire information about the viscoelastic properties
of brain tissues. Although the precision, repeatability,
and sensitivity to changes in these viscoelastic
parameters has been reported in phantoms and in vivo,
the accuracy of either the single-frequency or
multi-frequency stiffness measurements has not been
thoroughly evaluated experimentally. The objective of
this work was to evaluate the accuracy of both
single-frequency and multi-frequency brain MRE in a
geometrically accurate brain stiffness mimicking phantom
and compare it with mechanical testing.
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