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Abstract #2555

Prospective Motion Correction (PROMO) enabled MP2RAGE for multi-contrast high-resolution brain imaging

Alexandru V. Avram 1 , Joelle E. Sarlls 2 , Cibu P. Thomas 1,3 , Vinai Roopchansingh 4 , Dan Rettmann 5 , Ajit Shankaranarayanan 6 , and Peter J. Basser 1

1 Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States, 2 NINDS, National Institutes of Health, Bethesda, MD, United States, 3 The Henry Jackson Foundation, Bethes, MD, United States, 4 NIMH/Functional MRI Facility, National Institutes of Health, Bethesda, MD, United States, 5 ASL, GE Healthcare, Rochester, MN, United States, 6 ASL, GE Healthcare, Menlo Park, CA, United States

Images with different tissue contrasts acquired with the MP2RAGE pulse sequence, although inherently co-registered, can suffer from imaging artifacts due to subject motion especially in studies involving non-compliant subjects such as pediatric or elderly patient populations. We implement a PROMO-enabled 3D MP2RAGE pulse sequence, evaluate its ability to correct for subject motion, and illustrate how it can be used for multi-contrast high-resolution tissue visualization and characterization in moving subject at 3T.

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