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Abstract #2581

Biomimetic Phantom for Cardiac Diffusion Magnetic Resonance Imaging

Irvin Teh 1 , Penny L Hubbard Cristinacce 2,3 , Feng-Lei Zhou 2,4 , Geoffrey JM Parker 2,3 , and Jrgen E Schneider 1

1 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 2 Centre for Imaging Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, 3 Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom, 4 The School of Materials, The University of Manchester, Manchester, United Kingdom

There is increasing demand for phantoms to aid methods development in diffusion MRI, and to improve quality assurance of data. With the majority of phantoms designed to simulate brain tissue, we have designed a novel phantom, based on co-electrospinning, to simulate diffusion in the heart. The phantom was scanned with DTI over four weeks, and the average mean ADC and FA of 0.76 0.02 x 10 -3 mm 2 /s and 0.38 0.02 respectively, coincides with published ex-vivo preclinical data. Fibre tracking illustrates clearly the transition in helix angle, from -59 to 53 degrees, from the simulated subepicardium to subendocardium.

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