Influence of Metformin and Insulin on Myocardial Substrate Selection by 13C MRS

Coronary artery disease remains the leading case of mortality in the United States. The diabetes drug metformin has been shown to reduce cardiovascular morbidity and mortality in population based studies. The impact of metformin on myocardial metabolism has not been well characterized. In this study, we investigated the role of metformin on myocardial metabolism by 13C MRS. We demonstrated that metformin reversed insulin associated alterations in myocardial substrate selection.

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