Abstract #2586
A Pilot Study of Early Cognitive And Brain Imaging Changes Associated With Risk Factors for Cardiovascular Disease
Victoria X Wang 1 , Cheuk Tang 2 , Maryann McLaughlin 3 , Edmund Wong 1 , Johnny C Ng 1 , Lazar Fleysher 1 , Fayad A Zahi 4 , Maceda Cynara 5 , Heather N Beebe 6 , and Joseph Friedman 7
1
Radiology, Mount Sinai School of Medicine,
New York, NY, United States,
2
Radiology
& Psychiatry, Mount Sinai School of Medicine, New York,
NY, United States,
3
Cardiology
& Medicine, Mount Sinai School of Medicine, New York,
NY, United States,
4
Radiology
& Cardiology, Mount Sinai School of Medicine, New York,
NY, United States,
5
Cardiology,
Mount Sinai School of Medicine, New York, NY, United
States,
6
Mount
Sinai School of Medicine, New York, NY, United States,
7
Psychiatry,
Mount Sinai School of Medicine, New York, NY, United
States
Early cognitive impairments associated with CV disease
risk factors are subclinical, and are infrequently
identified during routine medical care. Such mild
cognitive impairments, even if not immediately obvious
to the physician, may impact preventive care, medication
adherence, clinical follow-up, and quality of life.
Cognitive impairment in individuals at risk for vascular
pathology, but who have not suffered clinical stroke,
suggests the presence of a cognitive prodrome for
vascular neurodegenerative disease. This cognitive
impairment likely reflects subclinical cerebral disease.
In this study we aim to investigate the severity of
cognitive changes using fMRI and DTI in otherwise
asymptomatic persons (no end organ damage) carrying CV
disease risk factors such as hypertension, diabetes
mellitus, hyperlipidemia, elevated BMI and smoking.
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