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Abstract #2585

High Resolution In Vivo Cardiac MRI of Zebrafish With An Integrated Coil Flow Cell Design

Gavin D Merrifield 1 , Lindsay Gallagher 1 , James Mullin 1 , Carl S Tucker 2 , Maurits A Jansen 2,3 , William M Holmes 1 , and Martin A Denvir 2

1 Glasgow Experimental MRI Centre, University of Glasgow, Glasgow, Glasgow, United Kingdom, 2 University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Midlothian, United Kingdom, 3 Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, Midlothian, United Kingdom

As an emerging biomedical model the development of Magnetic Resonance Imaging techniques for use in the zebrafish would prove particularly useful to many streams of in vivo research. However the exceptionally small size of this species compared to rodent models and it's unique aquatic environment provide several practical challenges to be overcome. We present a custom MRI compatible flow cell equipped with an integrated solenoid coil for successful imaging that meet those challenges.

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