Abstract #2600
Improved Accuracy of T1 Mapping Reconstruction Using a Novel Bloch Equation-based Fitting With Graphic Processing Unit Implementation
Sbastien Roujol 1 , Tamer A. Basha 1 , Jihye Jang 1 , Sophie Berg 1 , Warren J. Manning 1,2 , and Reza Nezafat 1
1
Department of Medicine, Beth Israel
Deaconess Medical Center and Harvard Medical School,
Boston, Massachusetts, United States,
2
Department
of Radiology, Beth Israel Deaconess Medical Center and
Harvard Medical School, Boston, Massachusetts, United
States
Native myocardial T1 sequences generally use a balanced
steady state free precession (b-SSFP) readout. However,
the b-SSFP signal is sensitive to many factors including
B0/B1 field inhomogeneities, T2, and magnetization
transfer. We recently developed the slice-interleaved T1
(STONE) sequence which we extended to spoiled gradient
echo (GRE) imaging. The GRE readout removes the T2
dependence and the magnetization transfer sensitivity of
T1 estimates, and reduces the overall sensitivity to B0
field inhomogeneities. Two-point fit model provides
improved robustness against artefact and provides higher
T1 precision. However, this model is associated with
reduced accuracy induced by its sensitivity to imperfect
inversion efficiency and signal disturbances caused by
the imaging pulses. In this study, we sought to develop
and evaluate an alternative fitting approach where the
data are fitted to the simulated signal of the entire
pulse sequence using Bloch equations.
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