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Abstract #2602

MRI visible bioscaffold for stem cell-mediated repair and improved cardiac function

Laurence H Jackson 1 , Thomas Roberts 1 , Valerie Taylor 1 , Josef Habib 2 , Daniel J Stuckey 1 , and Mark F Lythgoe 1

1 Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2 Imaging Sciences and Biomedical Engineering, Perinatal Imaging and Health, Kings College London, London, United Kingdom

In recent years it has become feasible to treat injured myocardium using regenerative cellular strategies. These techniques generally focus on the delivery of treatment cells to the myocardium and rely on their successful engraftment to existing tissue. The work presented here determines a method and the success of tracking bone marrow mononuclear cells suspended in gadolinium doped hydrogel within the myocardium. Correlating the presence of cells to changes to regional strain in the myocardium using tag-cine MRI then allows us to directly assess therapeutic success.

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