Abstract #2602
MRI visible bioscaffold for stem cell-mediated repair and improved cardiac function
Laurence H Jackson 1 , Thomas Roberts 1 , Valerie Taylor 1 , Josef Habib 2 , Daniel J Stuckey 1 , and Mark F Lythgoe 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, United Kingdom,
2
Imaging
Sciences and Biomedical Engineering, Perinatal Imaging
and Health, Kings College London, London, United Kingdom
In recent years it has become feasible to treat injured
myocardium using regenerative cellular strategies. These
techniques generally focus on the delivery of treatment
cells to the myocardium and rely on their successful
engraftment to existing tissue. The work presented here
determines a method and the success of tracking bone
marrow mononuclear cells suspended in gadolinium doped
hydrogel within the myocardium. Correlating the presence
of cells to changes to regional strain in the myocardium
using tag-cine MRI then allows us to directly assess
therapeutic success.
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