MONITORING THE RESORPTION OF MYOCARDIAL INFARCT IN THE PRESENCE AND ABSENCE OF CORONARY MICROEMBOLI USING MRI AND MICROSCOPY

The aim of this swine study was to longitudinally quantify microemboli effects on viability of previously ischemic myocardium using MRI (at 3 days and 5 weeks after intervention) and microscopy (5 weeks). Animals were subjected to 45min LAD coronary artery occlusion with and without microemboli. Delayed contrast enhanced MRI has the potential to detect additional loss of cellular integrity in ischemic myocardium exposed to microembolization, but with limited spatial resolution for quantifying true microinfarct compared to microscopy. Cardiac injury biomarkers suffer similar limitation. MRI may be useful in testing the efficacy of newer techniques designed to minimize microemboli during revascularization.

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