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Abstract #2609

Comparison of High Resolution T 2 * Mapping and Quantitative Susceptibility Mapping to Investigate Myocardial Microstructure in the Ex Vivo Rodent Heart

Eva Peper 1 , Till Huelnhagen 1 , Andreas Pohlmann 1 , Min-Chi Ku 1 , and Thoralf Niendorf 1,2

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrck Center for Molecular Medicine, Berlin, Germany, 2 Experimental and Clinical Research Center, a joint cooperation between the Charit Medical Faculty and the Max Delbrck Center, Berlin, Germany

This study investigates the tissue contrast for QSM of ex vivo rodent hearts at 9.4 T in comparison to T 2 * mapping. Results show that QSM can provide a higher contrast for myocardial fiber structures than magnitude images and T 2 * maps, without using contrast agents. Susceptibility maps showed good correlation with histological images from literature. This observation provides encouragement that QSM might be a useful tool for assessing myocardial microstructure and could provide further insights into myocardial fiber arrangement and myolaminar structure.

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