Abstract #2630
THE LEFT VENTRICULAR GLOBAL FUNCTION INDEX BY CARDIAC MAGNETIC RESONANCE IS MORE STRONGLY NEGATIVELY AFFECTED BY MYOCARDIAL IRON OVERLOAD THAN THE GLOBAL SYSTOLIC FUNCTION
Antonella Meloni 1 , Vincenzo Positano 1 , Antonino Vallone 2 , Paolo Preziosi 3 , Maria Chiara Resta 4 , Gennaro Restaino 5 , Maria Giovanna Neri 1 , Roberta Renni 6 , Monica Benni 7 , Petra Keilberg 1 , Cristina Salvatori 8 , and Alessia Pepe 1
1
CMR Unit, Fondazione G. Monasterio
CNR-Regione Toscana, Pisa, Italy,
2
Istituto
di Radiologia, Az. Osp. "Garibaldi" Presidio Ospedaliero
Nesima, Catania, Italy,
3
U.O.C.
Diagnostica per Immagini e Interventistica, Policlinico
Casilino", Roma, Italy,
4
Struttura
Complessa di Radiologia, OSP. SS. Annunziata ASL
Taranto, Taranto, Italy,
5
Dipartimento di
Radiologia, Universit Cattolica del Sacro Cuore,
Campobasso, Italy,
6
Day
Hospital, Ospedale Civile F. Ferrari, Casarano (LE),
Italy,
7
Servizio
di Immunoematologia e Centro Trasfusionale, Policlinico
S. Orsola "L. e A. Seragnoli", Bologna, Italy,
8
Unit
Operativa Sistemi Informatici, Fondazione G. Monasterio
CNR-Regione Toscana, Pisa, Italy
The left ventricular global function index (LVGFI) is a
functional parameter integrating structural as well as
mechanical behaviour. In the MESA study a LVGFI <37% was
shown to be strongly predictive of cardiovascular
events. In the present study, involving patients with
thalassemia major, we found out that different patterns
of myocardial iron overload evaluated by the T2*
multislice technique were more strongly associated with
a LVGFI <37% than with a LV dysfunction. Thus, a
LVGFI<37% could better identify a significant higher
risk of adverse cardiovascular events beyond heart
failure in iron loaded patients.
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