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Abstract #2631

Prospective Changes of Cardiac and Hepatic Iron and Cardiac Function in Low and Intermediate-1 Risk MDS Patients

Antonella Meloni 1 , Michele Rizzo 2 , Giovanni Carulli 3 , Esther Natalie Oliva 4 , Francesco Arcioni 5 , Sergio Storti 6 , Maria Giovanna Neri 1 , Stefania Renne 7 , Emanuele Grassedonio 8 , Gennaro Restaino 9 , Vincenzo Positano 1 , and Alessia Pepe 1

1 CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2 Reparto di Ematologia, Azienda Sanitaria Provinciale Caltanissetta - Ospedale Sant'Elia, Caltanisetta, Italy, 3 Dip. di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina Divisione di Ematologia, Facolt di Medicina e chirurgia Universit degli Studi di Pisa, Pisa, Italy, 4 Hematology Unit, A.O. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy, 5 Dipartimento di Medicina Clinica e Sperimentale, Universit degli Studi di Perugia, Perugia, Italy, 6 UOC di Onco-Ematologia, Universit Cattolica del Sacro Cuore, Campobasso, Italy, 7 Struttura Complessa di Cardioradiologia-UTIC, P.O. Giovanni Paolo II, Lamezia Terme, Italy, 8 Dipartimento di Radiologia, Policlinico "Paolo Giaccone", Palermo, Italy, 9 Dipartimento di Radiologia, Universit Cattolica del Sacro Cuore, Campobasso, Italy

The aim of our study was to assess the changes in cardiac and hepatic iron overload and the morpho-functional cardiac parameters by MRI in myelodysplastic patients who performed the follow-up (FU) MRI at 12 months. The new occurrences of cardiac iron, reduced cardiac function, increased LV and RV EDVI and myocardial fibrosis and the worsening in MRI LIC (liver iron concentration) values suggest the need of performing periodic MRI scans, in order to better manage these patients.

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