Abstract #2636
Can quantitative texture analysis on cardiac magnetic resonance differentiate hypertrophic cardiomyopathy patients at high risk of sudden cardiac death and candidates for implantable cardioverter-defibrillator placement from those at low risk?
Rebecca E Thornhill 1,2 , Julie Robillard 3,4 , Michael Gollob 5 , Carole Dennie 1,2 , Alexander Dick 6,7 , Edith Kolozsi 6 , and Elena Pena 1,2
1
Medical Imaging, The Ottawa Hospital,
Ottawa, ON, Canada,
2
Radiology,
University of Ottawa, Ottawa, ON, Canada,
3
Radiology,
Montreal Heart Institute, Montreal, PQ, Canada,
4
Radiologie,
Universit de Montral, Montreal, PQ, Canada,
5
Electrophysiology,
Peter Munk Cardiac Centre, Toronto, ON, Canada,
6
Cardiology,
University of Ottawa Heart Institute, Ottawa, ON,
Canada,
7
Medicine,
University of Ottawa, Ottawa, ON, Canada
Evidence of late gadolinium enhancement (LGE) has been
associated with the development of arrhythmias and
sudden cardiac death (SCD) in patients with hypertrophic
cardiomyopathy (HCM). One of the challenges is how to
improve the predictive value of LGE in HCM as
enhancement may appear heterogeneous. Texture analysis
was applied to quantify enhancement heterogeneity in HCM
patients considered at high risk of SCD and those who
are not. These features were significantly elevated in
patients considered at high risk of SCD, even in
non-hypertrophic, non-fibrotic segments (ie, normal
appearing). Quantitative textural features show
potential for assisting in risk stratification in HCM.
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