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Abstract #2655

Optimizing T1w-SPACE for intracranial arterial imaging

Lei Zhang 1 , Jaeseok Park 2 , Jun Wu 3 , Xin Liu 1 , and Yiu-Cho Chung 1

1 Paul C. Lauterbur Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academic of Sciences, Shenzhen, Guangdong, China, 2 department of brain and cognitive engineering, Korea university, Seoul, Korea, 3 Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

Intracranial atherosclerosis can be imaged using 3DTSE variants such as T1w-SPACE. T1w-SPACE needs high SNR for high resolution imaging. Meanwhile, the high CSF signal around the intracranial vessels must be low so that vessel wall can be reliably detected. This can be achieved using a previously proposed flip-down pulse. However, the pulse reduces both CSF signal and image SNR. In this study, an application specific signal profile for T1w-SPACE is proposed to compensate for the SNR loss caused by the flip-down pulse. The net result is improved contrast between vessel wall and CSF with little effect on overall image SNR.

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