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Abstract #2658

In vivo quantification and correlation of intracranial aneurysm wall thickness and wall shear stress

Roos Blankena 1,2 , Rachel Kleinloog 1 , Pim van Ooij 3 , Bon Verweij 1 , Bennie ten Haken 2 , and Jaco Zwanenburg 4

1 Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Technical Medicine, University of Twente, Enschede, Overijssel, Netherlands, 3 Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Noord-Holland, Netherlands, 4 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

In-vivo assessment of the aneurysm wall thickness in combination with wall shear stress (WSS), may provide new insights in the development of the aneurysm. Using high-resolution 7T images of the vessel wall, in vivo aneurysm wall thickness was compared with WSS, obtained from PCA measurements. A preliminary analysis was performed, including 9 unruptured aneurysms of 7 patients. All analysed patients showed variations in wall thickness. A negative correlation between local wall thickness and WSS was found in almost all aneurysms. This is the first study presenting a correlation of local wall thickness with WSS from in vivo measurements.

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