Abstract #2661
Quantitative MR imaging of ex vivo intracranial atherosclerotic plaques at 7.0 tesla
A.A. Harteveld 1 , N.P. Denswil 2 , J.C.W. Siero 1 , J.J.M. Zwanenburg 1,3 , A. Vink 4 , W.G.M. Spliet 4 , P.R. Luijten 1 , M.J. Daemen 2 , J. Hendrikse 1 , and A.G. van der Kolk 1
1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
2
Department
of Pathology, Academic Medical Center, Amsterdam,
Netherlands,
3
Image Sciences Institute,
University Medical Center Utrecht, Utrecht, Netherlands,
4
Department
of Pathology, University Medical Center Utrecht,
Utrecht, Netherlands
In recent years, several intracranial vessel wall
imaging techniques using (ultra)high-field MRI have
emerged for the evaluation and characterization of
atherosclerotic vessel wall lesions in vivo. However, a
thorough validation of MRI results of intracranial
plaques with histopathology is still lacking. The
purpose of this study was to validate the signal
characteristics of different intracranial plaque
components with quantitative MRI at 7 tesla using
post-mortem circle of Willis specimen. The presented
ultrahigh-resolution MR imaging protocol shows that
different atherosclerotic plaque components can be
identified and characterized using multi-parametric
quantitative T1, T2, T2* and PD images.
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