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Abstract #2661

Quantitative MR imaging of ex vivo intracranial atherosclerotic plaques at 7.0 tesla

A.A. Harteveld 1 , N.P. Denswil 2 , J.C.W. Siero 1 , J.J.M. Zwanenburg 1,3 , A. Vink 4 , W.G.M. Spliet 4 , P.R. Luijten 1 , M.J. Daemen 2 , J. Hendrikse 1 , and A.G. van der Kolk 1

1 Department of Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Department of Pathology, Academic Medical Center, Amsterdam, Netherlands, 3 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 4 Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands

In recent years, several intracranial vessel wall imaging techniques using (ultra)high-field MRI have emerged for the evaluation and characterization of atherosclerotic vessel wall lesions in vivo. However, a thorough validation of MRI results of intracranial plaques with histopathology is still lacking. The purpose of this study was to validate the signal characteristics of different intracranial plaque components with quantitative MRI at 7 tesla using post-mortem circle of Willis specimen. The presented ultrahigh-resolution MR imaging protocol shows that different atherosclerotic plaque components can be identified and characterized using multi-parametric quantitative T1, T2, T2* and PD images.

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