Cerebral Angiography and Vessel Wall in Progressive Hypertension
Yunxia Li 1,2 , Qiang Shen 1 , Shiliang Huang 1 , Wei Li 1 , Eric R Muir 1 , Justin Alexander Long 1 , and Timothy Q Duong 1
Research Imaging Institute, The University
of Texas Health Science Center at San Antonio, San
Antonio, TX, United States,
of Neurology, Tongji Hospital, Tongji University,
Chronic hypertension increases susceptibility to
neurological disorders. The goal of this study was to
evaluate the morphology of cerebral arteries using MRA
and vessel-wall imaging in an established rat model of
hypertension (SHR) at different stages of the disease
progression. Comparisons were made with age-matched
normotensive Wistar Kyoto (WKY) rats. CBF and CR were
altered in early stage of chronic hypertension and
worsen with disease progression, ultimately resulting
hypoperfusion and compromised cerebrovascular reserve.
MRI has the potential to be used to identify brain
regions susceptible to hemodynamic compromise, improve
understanding of disease pathogenesis, and guide
treatments in hypertension.
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