Abstract #2691
Reducing Saturation Effects in the AIF Determination of Quantitative First-Pass Perfusion Imaging Using a Model-based Reconstruction
Johannes Tran-Gia 1 , David Lohr 1 , Andreas M. Weng 1 , Christian O. Ritter 1,2 , Thorsten A. Bley 1 , and Herbert Kstler 1
1
Department of Diagnostic and Interventional
Radiology, University of Wrzburg, Wrzburg, Germany,
2
Department
of Diagnostic and Interventional Radiology, University
Medical Center Gttingen, Gttingen, Germany
In this work, an approach for the determination of
unsaturated AIFs is presented and validated. For this
purpose, a model-based reconstruction is applied to
myocardial first-pass perfusion datasets acquired with a
radial saturation-recovery prepared FLASH sequence to
reconstruct a contrast agent dynamic for a recovery time
of ~3ms. This extremely short recovery time promises the
determination of an unsaturated AIF. To assess any
saturation effects, the AIFs obtained in 6 healthy
volunteers using the proposed method were compared to a
dual-bolus AIF determination. Additionally, absolute
perfusion values were determined to investigate the
influence of saturated AIFs on the quantification.
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