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Abstract #2691

Reducing Saturation Effects in the AIF Determination of Quantitative First-Pass Perfusion Imaging Using a Model-based Reconstruction

Johannes Tran-Gia 1 , David Lohr 1 , Andreas M. Weng 1 , Christian O. Ritter 1,2 , Thorsten A. Bley 1 , and Herbert Kstler 1

1 Department of Diagnostic and Interventional Radiology, University of Wrzburg, Wrzburg, Germany, 2 Department of Diagnostic and Interventional Radiology, University Medical Center Gttingen, Gttingen, Germany

In this work, an approach for the determination of unsaturated AIFs is presented and validated. For this purpose, a model-based reconstruction is applied to myocardial first-pass perfusion datasets acquired with a radial saturation-recovery prepared FLASH sequence to reconstruct a contrast agent dynamic for a recovery time of ~3ms. This extremely short recovery time promises the determination of an unsaturated AIF. To assess any saturation effects, the AIFs obtained in 6 healthy volunteers using the proposed method were compared to a dual-bolus AIF determination. Additionally, absolute perfusion values were determined to investigate the influence of saturated AIFs on the quantification.

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