Evaluation of cardiac stress perfusion and functional MRI biomarkers in healthy nonhuman primates: Reproducibility and repeatability study
Sarayu Parimal 1,2 , Smita Sampath 1,2 , Michael Klimas 2 , Dai Feng 3 , Richard Baumgartner 3 , Elaine Manigbas 4 , Willy GSell 4 , Jeffrey L. Evelhoch 2 , and Chin Chih-Liang 1,2
Imaging, MSD, Singapore,
Merck & Co. Inc., WestPoint, Philadelphia, United
Research, Biostatistics and Research Decision Sciences,
Merck & Co. Inc., Rahway, New Jersey, United States,
department, Maccine Pte Ltd, Singapore
Nonhuman primate models of human diseases offer unique
platforms to evaluate novel therapeutics with better
translatability to patients, where imaging biomarkers
revealing early disease progression or treatment
responses can be critical. Cardiac dysfunction and
perfusion abnormalities at stress are early hallmarks of
underlying disease. Herein, the robustness of cardiac
function/perfusion biomarkers in healthy nonhuman
primates during inotropic stress was evaluated. We found
good inter- and intra- observer reproducibility for
perfusion and functional reserves. Inter-study
repeatability was higher for perfusion reserve.
Significant differences between rest and stress existed
for peak circumferential strain and myocardial blood
flow, but not for diastolic strain-rate.
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