Abstract #2694
The Influence of Contrast Agent Bolus Dispersion in Contrast-Enhanced Myocardial Perfusion MRI: A Computational Fluid Dynamics Simulation Study on Influencing Factors and Different Methods of Quantitative Analysis
Regine Schmidt 1 , Dirk Graafen 1,2 , Karsten Sommer 1 , Hanns-Christian Breit 1 , and Laura Maria Schreiber 1,3
1
Section of Medical Physics, Department of
Radiology, Johannes Gutenberg University Medical Center,
Mainz, Germany,
2
Department
of Radiology, Johannes Gutenberg University Medical
Center, Mainz, Germany,
3
Department
of Cellular and Molecular Imaging, Comprehensive Heart
Failure Center (CHFC), Wuerzburg, Germany
The contrast agent bolus dispersion at myocardial
perfusion MRI was examined for a stenotic coronary
bifurcation geometry by using computational fluid
dynamics simulations. Different flow conditions through
the stenotic branch were considered. Simulation results
were analyzed quantitatively with MMID4 (a) and the
Fermi function model (b). A non-negligible
underestimation of myocardial blood flow of up to -16.1%
(a) and -11.4% (b) and an overestimation of the
myocardial perfusion reserve of up to 7.5% (a) and 10.0%
(b) were found. In additional simulations the influence
of the erythrocytes in blood on the contrast agent bolus
dispersion was found to be non-negligible.
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