MRI PERFUSION DISCRIMINATES STUNNED MYOCARDIUM ADJACENT TO FOCAL INFARCT FROM MICROEMBLIZED INFARCTED MYOCARDIUM

Myocardial perfusion and function was assessed in ischemic myocardium with and without microemboli using MRI and postmortem histomorphometry. Pigs (n=24) served as controls or were subjected to brief coronary artery occlusion with and without microemboli. MRI was used at 3 days and 5 weeks to acquire cine and perfusion images. It was found that perfusion MRI has the ability to differentiate mildly ischemic from microembolized ischemic myocardium, while cine MRI demonstrated the severity of injury at global level. The combination of cine and perfusion MRI showed persistent myocardial stunning and perfusion deficits in mildly ischemic myocardium with minor infarction.

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