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Abstract #2707

Intravoxel Incoherent Motion and Arterial Spin Labeling MRI of Isolated Perfused Hearts

Osama Abdullah 1 , Arnold David Gomez 1 , Samer Merchant 1 , Michael Heidinger 2 , Steven Poelzing 2 , and Edward W Hsu 1

1 Bioengineering, University of Utah, Salt Lake City, Utah, United States, 2 Cardiac Research and Training Institute, University of Utah, Utah, United States

Intravoxel incoherent motion (IVIM) was investigated in an animal model of isolated perfused heart as functions of myocardial blood flow (MBF) and diffusion encoding direction. The IVIM-derived mean blood velocity (D*) and volume fraction (VF) were correlated to independent measure of MBF using arterial spin labeling. The D* was faster in the direction parallel than perpendicular to myofibers at normal inflow pressures. The VF had a strong dependence on MBF but not myofiber orientation. Collectively, results indicate that IVIM parameters in the myocardium depend on microcirculation and myofiber orientation in consistent fashions with the hearts known anatomy and circulation physiology.

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