Comparison of first-pass MRI and arterial spin labeling for quantification of myocardial perfusion in mice
Nivedita K. Naresh 1 , Xiao Chen 1 , Yikui Tian 2 , Eric M. Moran 1 , Brent A. French 1 , and Frederick H. Epstein 1,3
Biomedical Engineering, University of
Virginia, Charlottesville, Virginia, United States,
University of Virginia Health System, Charlottesville,
Virginia, United States,
University of Virginia, Virginia, United States
Myocardial blood flow (MBF) imaging in mice can be used
to study mechanisms underlying heart disease. We
compared first-pass MRI and ASL for perfusion imaging in
C57Bl/6 mice in terms of image quality, repeatability
and user variability under different conditions: rest,
stress and after myocardial infarction. Image quality
was better with ASL under all conditions. Repeatability
was better with first-pass MRI at low MBF conditions
such as infarct imaging. User variability was better
with ASL at high MBF conditions such as stress imaging.
Our results may be useful in planning future studies
investigating perfusion abnormalities in heart diseases.
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