Abstract #2709
Alterations of left atrial function and substrate after myocardial infarction in relation to vulnerability for atrial fibrillation: A chronic porcine model
Dana C Peters 1 , Stephanie L Thorn 2 , Alda Bregasi 2 , Edgar J Diaz 1 , Mitchel R Stacy 2 , Christi Hawley 2 , and Albert J Sinuas 2
1
Radiology, Yale School of Medicine, New
Haven, CT, United States,
2
Cardiology,
Yale School of Medicine, New Haven, CT, United States
Our study focused on determining the acute effects of
myocardial infarction on left atrial (LA) function and
myocardial injury, with the hypothesis that myocardial
infarction may lead to changes in atrial mechanics,
which will result in acute inflammation and later
fibrosis. Furthermore, we investigated whether atrial
fibrillation (AF) inducibility after myocardial
infarction correlates to changes in the LA function and
substrate. Atrial remodeling after myocardial infarction
was studied in 6 control swine and 9 pigs post-MI. LA
volumes were increased after infarction. The atrial
fibrosis volume by LGE trended greater in pigs with AF
inducibility (6/9 post-MI and 0/6 controls).
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