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Abstract #2709

Alterations of left atrial function and substrate after myocardial infarction in relation to vulnerability for atrial fibrillation: A chronic porcine model

Dana C Peters 1 , Stephanie L Thorn 2 , Alda Bregasi 2 , Edgar J Diaz 1 , Mitchel R Stacy 2 , Christi Hawley 2 , and Albert J Sinuas 2

1 Radiology, Yale School of Medicine, New Haven, CT, United States, 2 Cardiology, Yale School of Medicine, New Haven, CT, United States

Our study focused on determining the acute effects of myocardial infarction on left atrial (LA) function and myocardial injury, with the hypothesis that myocardial infarction may lead to changes in atrial mechanics, which will result in acute inflammation and later fibrosis. Furthermore, we investigated whether atrial fibrillation (AF) inducibility after myocardial infarction correlates to changes in the LA function and substrate. Atrial remodeling after myocardial infarction was studied in 6 control swine and 9 pigs post-MI. LA volumes were increased after infarction. The atrial fibrosis volume by LGE trended greater in pigs with AF inducibility (6/9 post-MI and 0/6 controls).

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