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Abstract #2712

Development of Real-time Magnetic Resonance Imaging of Mouse Hearts at 9.4 Tesla Simulations and First Applications

Tobias Wech 1 , Nicole Seiberlich 2 , Andreas Schindele 3 , Michael L. Gyngell 4 , Valentina Davidoiu 5 , Alfio Borzi 3 , Herbert Kstler 1 , and Jrgen E. Schneider 6

1 Department of Diagnostic and Interventional Radiology, University of Wuerzburg, Wrzburg, Germany, 2 Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3 Institute of Mathematics, University of Wuerzburg, Wrzburg, Germany, 4 Perspectum Diagnostics Ltd, Oxford, United Kingdom, 5 Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 6 Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

The feasibility of performing real time imaging to assess cardiac function in mice at 9.4 T was explored. A radial gradient echo sequence was applied to acquire highly undersampled data without cardiac and/or respiratory gating. Radial GRAPPA and Compressed Sensing were combined to obtain fully sampled data. The method was first optimized in simulations and then applied to three mice in vivo. Left-ventricular volumes and ejection fractions quantified from a mid-ventricular slice agreed well with corresponding fully sampled segmented cine acquisitions. Our work indicates that it is possible to accurately measure LV function in mice with real-time MRI.

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