Abstract #2712
Development of Real-time Magnetic Resonance Imaging of Mouse Hearts at 9.4 Tesla Simulations and First Applications
Tobias Wech 1 , Nicole Seiberlich 2 , Andreas Schindele 3 , Michael L. Gyngell 4 , Valentina Davidoiu 5 , Alfio Borzi 3 , Herbert Kstler 1 , and Jrgen E. Schneider 6
1
Department of Diagnostic and Interventional
Radiology, University of Wuerzburg, Wrzburg, Germany,
2
Biomedical
Engineering, Case Western Reserve University, Cleveland,
OH, United States,
3
Institute
of Mathematics, University of Wuerzburg, Wrzburg,
Germany,
4
Perspectum
Diagnostics Ltd, Oxford, United Kingdom,
5
Division
of Imaging Sciences & Biomedical Engineering, King's
College London, London, United Kingdom,
6
Division
of Cardiovascular Medicine, University of Oxford,
Oxford, United Kingdom
The feasibility of performing real time imaging to
assess cardiac function in mice at 9.4 T was explored. A
radial gradient echo sequence was applied to acquire
highly undersampled data without cardiac and/or
respiratory gating. Radial GRAPPA and Compressed Sensing
were combined to obtain fully sampled data. The method
was first optimized in simulations and then applied to
three mice in vivo. Left-ventricular volumes and
ejection fractions quantified from a mid-ventricular
slice agreed well with corresponding fully sampled
segmented cine acquisitions. Our work indicates that it
is possible to accurately measure LV function in mice
with real-time MRI.
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