Abstract #2713
Assessing Diastolic Function in Mouse Hearts: High-temporal resolution CINE MRI vs. Ultrasound
Thomas A Roberts 1 , Anthony N Price 2 , Anna L David 3 , Valerie Taylor 1 , Daniel J Stuckey* 1 , and Mark F Lythgoe* 1
1
Centre for Advanced Biomedical Imaging,
Division of Medicine, University College London, London,
United Kingdom,
2
Division
of Imaging Sciences and Biomedical Engineering, London,
United Kingdom,
3
Institute
for Womens Health, University College London, London,
United Kingdom
Common measures of systolic cardiac function often fail
to detect heart failure. Many patients present with
preserved ejection fraction despite underlying
pathology. Therefore, a more sensitive measure of heart
failure is required. In this study, a high-temporal
resolution (HTR-) CINE sequence (approximately one frame
every millisecond) is presented for the assessment of
diastolic function in mice. The performance of the
sequence is compared against Doppler ultrasound, which
is the established method for assessing diastolic
function. Repeatability of the HTR-CINE sequence is
shown to be comparable to ultrasound in a cohort of
nave mice. In a cohort of infarcted mice, HTR-CINE MRI
is found to be more sensitive at detecting heart failure
compared to ultrasound.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
