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Abstract #2713

Assessing Diastolic Function in Mouse Hearts: High-temporal resolution CINE MRI vs. Ultrasound

Thomas A Roberts 1 , Anthony N Price 2 , Anna L David 3 , Valerie Taylor 1 , Daniel J Stuckey* 1 , and Mark F Lythgoe* 1

1 Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom, 2 Division of Imaging Sciences and Biomedical Engineering, London, United Kingdom, 3 Institute for Womens Health, University College London, London, United Kingdom

Common measures of systolic cardiac function often fail to detect heart failure. Many patients present with preserved ejection fraction despite underlying pathology. Therefore, a more sensitive measure of heart failure is required. In this study, a high-temporal resolution (HTR-) CINE sequence (approximately one frame every millisecond) is presented for the assessment of diastolic function in mice. The performance of the sequence is compared against Doppler ultrasound, which is the established method for assessing diastolic function. Repeatability of the HTR-CINE sequence is shown to be comparable to ultrasound in a cohort of nave mice. In a cohort of infarcted mice, HTR-CINE MRI is found to be more sensitive at detecting heart failure compared to ultrasound.

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