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Abstract #2733

Fast Quantification of Global Cerebral Metabolic Rate of Oxygen (CMRO 2 )

Suliman Barhoum 1 , Michael C. Langham 1 , Jeremy F. Magland 1 , Chamith S. Rajapakse 1 , Cheng Li 1 , and Felix W. Wehrli 1

1 Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

The cerebral metabolic rate of oxygen consumption (CMRO 2 ) is an important, tightly regulated, physiologic parameter. A recently reported quantitative MRI method denoted OxFlow has been shown to be able to quantify whole-brain CMRO 2 by simultaneously measuring oxygen saturation (SvO 2 ) and cerebral blood flow (CBF) in the major vessels draining and feeding the brain in 30 seconds, which is typically adequate for measurement at baseline but not necessarily in response to neuronal activation. Here, we present an improved version of the pulse sequence that quantifies CMRO 2 in 10 seconds scan time and compared it with the parent sequence in eight subjects. Results indicate good agreement between both sequences, with mean differences of 2%, 3%, and 1% for SvO 2 , CBF, and CMRO 2 , respectively.

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