Monte Carlo diffusion simulations disambiguate the biophysical mechanisms of diffusion hinderance along tracts
Michiel Kleinnijenhuis 1 , Jeroen Mollink 1 , Paul Kinchesh 2 , Wilfred W Lam 1 , Vitaly L Galinsky 3 , Lawrence R Frank 3 , Sean C Smart 2 , Saad Jbabdi 1 , and Karla L Miller 1
FMRIB Centre, University of Oxford, Oxford,
of Oncology, University of Oxford, Oxford, United
for Scientific Computation in Imaging, University of
California San Diego, La Jolla, United States
Fibre tracts are generally assumed to be very coherent
in their microstructure. Along the fibres, little
hinderence to diffusion would then be expected.
Diffusion properties along tracts can be investigated at
long diffusion times, where longer length scales can be
probed. This study assessed the diffusion time
dependence of the apparent diffusion coefficient along
the fibres of the human corpus callosum (often thought
as the most coherent bundle) with post mortem STEAM DWI.
The biophysical substrate of this relation was
interpreted with aid of Monte Carlo diffusion
simulations in a range of axon models, representing
bending, fanning and undulating configurations.
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