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Abstract #2757

Theoretical study of the free water elimination model

Quinten Collier 1 , Jelle Veraart 1,2 , Ben Jeurissen 1 , Arnold J. den dekker 1,3 , and Jan Sijbers 1

1 iMinds-Vision Lab, University of Antwerp, Antwerp, Antwerp, Belgium, 2 Center for Biomedical Imaging, New York University Langone Medical Center, New York, New York, United States, 3 Delft Center for System and Control, Delft University of Technology, Delft, Netherlands

Partial volume effects caused by cerebrospinal fluid are an important issue in diffusion MRI. In this work, we study the free water elimination model by analyzing the Cramr-Rao lower bound (CRLB) of its parameters. We show that through optimizing the acquisition protocol by minimizing the trace of the CRLB, a significant gain in the precision of the parameter estimation can be achieved. Moreover, further analysis indicates that regularization and/or constraints are necessary for parameter estimation from voxels with large CSF fractions and/or low FA values. These theoretical findings are confirmed by both simulation and real data experiments.

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