A highly standardized, easy to produce and cost-effective isotropic PVP diffusion phantom for quality assessment and multi-center studies

There is a need for highly standardized isotropic diffusion phantoms. Most isotropic phantoms are difficult to manufacture in large quantities, are difficult to obtain, are expensive, contain toxic or flammable substances and/or require careful handling, which makes them unsuitable for use in a clinical setting. For CENTER-TBI, a large European multi-center study to investigate effective treatments for traumatic brain injury in a clinical environment, 35 phantoms were needed. We have created an easy to use, robust, cost-effective, and safe isotropic diffusion phantom, which can be produced in a reproducible way.

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