Efficient Gradient Calibration based on Diffusion MRI

Diffusion MRI is particularly sensitive to the calibration of the gradient system. We present a simple and efficient method for gradient calibration based on comparing the measured apparent diffusion coefficient (ADC) in the x, y and z directions in an isotropic cyclooctane phantom, with known reference values, at a given measured temperature. Pre-calibration measurements of ADC differed by up to 8.5x10 ^-5 mm ² /s between directions, leading to an elevated fractional anisotropy (FA) value of 0.10. Post-calibration values of ADC and FA were 0.9x10 ^-5 mm ² /s and 0.03 respectively. The calibration also benefits geometric accuracy as demonstrated with high-resolution anatomical imaging.

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