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Abstract #2762

Quantitative Quality Assurance Metrics in a High Angular Resolution Diffusion Imaging (HARDI) Multicenter Study

Xiaopeng Zhou 1 , Ken Sakaie 1 , Josef Debbins 2 , Robert Fox 1 , and Mark Lowe 1

1 The Cleveland Clinic, Cleveland, OH, United States, 2 Barrow Neurological Institute, Phoenix, AZ, United States

In a multicenter trial, QA metrics are necessary to provide confidence in data quality and indicate when scanner repairs may be necessary. Quantitative assessment may provide the ability to detect subtle degradation in scanner performance, offering an opportunity to repair the scanner proactively. An important result would be to avoid costly repeat scans or lost data in a multicenter trial. We propose a receiver operating characteristic (ROC) analysis to establish quantitative thresholds on SNR. We demonstrate the use of this method on phantom data acquired from 27 sites in the SPRINT-MS, a phase II trial of treatment for progressive multiple sclerosis.

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