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Abstract #2767

In vivo mouse brain NODDI acquired at 9.4T using cryogenic probe

Van Thu Nguyen 1 , Farshid Sepehrband 1 , Othman Alomair 1 , Suyinn Chong 2 , Karine Mardon 1 , Quang Tieng 1 , Graham Galloway 1 , and Nyoman Kurniawan 1

1 Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia, 2 Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia

While some studies have used NODDI (Neurite Orientation Dispersion and Density Imaging) to analyze human diffusion data, there has not been any study on animal models. This study fitted NODDI model to two HARDI (High-angular Resolution Diffusion-weighted Imaging) shell data (2 b-values and 30 gradient directions) obtained from the wild type mouse brains. The parameter maps obtained with NODDI reflect known brain anatomy and are consistent with fractional anisotropy (FA) maps obtained with DTI processing, and can be considered a complement to DTI by offering additional information of neurite density and their orientation dispersion in both gray and white matters.

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