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Abstract #2768

ABTIN: ABsolute TIssue density from NODDI, focusing on myelin density

Farshid Sepehrband 1,2 , Kristi A Clark 3 , Jeremy F. P Ullmann 1 , Nyoman D Kurniawan 1 , Gayeshika Leanage 1 , David C Reutens 1 , and Zhengyi Yang 1,4

1 Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia, 2 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia, 3 Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, California, United States, 4 School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, Australia

This work describes a quantitative approach to obtain absolute tissue density, focusing on fiber density, directly from diffusion magnetic resonance imaging. Such measures can be used to map brain fiber and cell densities and to quantitatively characterize disease progression. The proposed technique uses prior knowledge of myelin and cell membrane densities to correlate relative intra-cellular and intra-neurite density values obtained from diffusion magnetic resonance imaging to absolute tissue density values. The proposed method is based on the NODDI (neurite orientation distribution and density imaging) technique, which can be scanned with clinically feasible acquisition protocol.

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