Meeting Banner
Abstract #2769

MRI measurement of three-dimensional morphological features of axons

Dan Benjamini 1,2 and Peter J Basser 1

1 National Institute of Health, Bethesda, MD, United States, 2 Tel Aviv University, Tel Aviv, Israel

We present an analytical framework to measure the nonparametric joint radius-length (R-L) distribution of an ensemble of finite cylindrical pores, and more generally, the eccentricity distribution of anisotropic pores. Employing a 3-D d-PFG acquisition scheme, we first obtain both the marginal radius and length distributions, and then use these to constrain and stabilize the estimate of the joint radius-length distribution, using a feasible number of acquisitions. Axons are known to exhibit local compartment eccentricity variations upon injury; the extent of the variations depends on the severity of the injury. Reconstructing the eccentricity distribution may provide information about changes resulting from injury or development.

This abstract and the presentation materials are available to members only; a login is required.

Join Here