Meeting Banner
Abstract #2771

Reconstruction of size distribution of cellular-sized pores using DWI with clinically applicable gradients

Yaniv Katz 1 , Dan Benjamini 1,2 , Peter J Basser 2 , and Uri Nevo 1

1 Biomedical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel, 2 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, United States

Here we present our successful accurate estimation of pore size distributions, with pores sizes of typical cellular sizes, by the use of clinically applicable pulsed field gradients. We used a double pulsed field gradient (dPFG) diffusion weighted imaging scheme, with analysis that is based on the Multiple Correlation Function framework. We used a well calibrated phantom and demonstrate successful reconstruction of polydisperse distributions, composed of up to 3 different pores radii, with different volume fractions. These results demonstrate that the q value limit (size<1/q) can be broken, and biological cellular sizes can potentially be estimated using a dPFG pulse sequence.

This abstract and the presentation materials are available to members only; a login is required.

Join Here