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Abstract #2772

Neurite Density Imaging (NDI): rapid acquisition and estimation of the intracellular volume fraction.

Bjrn Lampinen 1 , Danielle van Westen 2,3 , Freddy Sthlberg 1,2 , Jimmy Ltt 3 , Oskar Hansson 4 , and Markus Nilsson 5

1 Dpt. of Medical Radiation Physics, Lund University, Lund, Sweden, 2 Dpt. of Diagnostic Radiology, Lund University, Lund, Sweden, 3 Imaging and function, Skane University Health Care, Lund, Sweden, 4 Clinical Memory Research Unit, Clinical Sciences, Malm, Lund University, Lund, Sweden, 5 Lund University Bioimaging Center, Lund University, Lund, Sweden

Neurite density imaging (NDI) is a fast method for obtaining the intracellular volume fraction, or neurite density, from neurite orientation dispersion and density imaging (NODDI). By using powder averaging of the signal to induce full orientation dispersion, NDI simplifies the NODDI model and reduces the acquisition and analysis time. We show that NDI produces accurate neurite density maps from data acquired in only five minutes, thus cutting the minimum acquisition time in half. The method is employed here to disambiguate the cause of elevated FA in the hippocampal cingulum in patients with Parkinsons disease dementia (PDD).

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