Abstract #2772
Neurite Density Imaging (NDI): rapid acquisition and estimation of the intracellular volume fraction.
Bjrn Lampinen 1 , Danielle van Westen 2,3 , Freddy Sthlberg 1,2 , Jimmy Ltt 3 , Oskar Hansson 4 , and Markus Nilsson 5
1
Dpt. of Medical Radiation Physics, Lund
University, Lund, Sweden,
2
Dpt.
of Diagnostic Radiology, Lund University, Lund, Sweden,
3
Imaging
and function, Skane University Health Care, Lund,
Sweden,
4
Clinical
Memory Research Unit, Clinical Sciences, Malm, Lund
University, Lund, Sweden,
5
Lund
University Bioimaging Center, Lund University, Lund,
Sweden
Neurite density imaging (NDI) is a fast method for
obtaining the intracellular volume fraction, or neurite
density, from neurite orientation dispersion and density
imaging (NODDI). By using powder averaging of the signal
to induce full orientation dispersion, NDI simplifies
the NODDI model and reduces the acquisition and analysis
time. We show that NDI produces accurate neurite density
maps from data acquired in only five minutes, thus
cutting the minimum acquisition time in half. The method
is employed here to disambiguate the cause of elevated
FA in the hippocampal cingulum in patients with
Parkinsons disease dementia (PDD).
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