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Abstract #2780

Oscillating Gradient Diffusion MRI as a Biomarker for Early Detection of Radiation Therapy Response

Andre Bongers 1 , Han Shen 2 , Erika Davies 1 , and Eric Hau 2,3

1 Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia, 2 Adult Cancer Program, University of New South Wales, Sydney, NSW, Australia, 3 Cancer Care Centre, St George Hospital, NSW, Australia

This study investigates the value of Oscillating Gradient Diffusion Weighted Imaging (OGSE DWI) to gain information about tumour radiation therapy response. 6 U87 glioblastoma bearing nude mice were separated into an irradiated and control arm and examined with an in-house developed cos-OGSE (f=200Hz) sequence in a pre-clinical scanner. Resulting ADC maps were statistically investigated and compared to corresponding PGSE ADC maps. Average ADC values from OGSE DWI were significantly higher in tumours than in normal tissue and showed significant increase after radiation therapy. ADC response to therapy in OGSE proved to be significantly stronger and earlier than corresponding PGSE ADCs.

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