Abstract #2780
Oscillating Gradient Diffusion MRI as a Biomarker for Early Detection of Radiation Therapy Response
Andre Bongers 1 , Han Shen 2 , Erika Davies 1 , and Eric Hau 2,3
1
Mark Wainwright Analytical Centre,
University of New South Wales, Sydney, NSW, Australia,
2
Adult
Cancer Program, University of New South Wales, Sydney,
NSW, Australia,
3
Cancer Care Centre, St George
Hospital, NSW, Australia
This study investigates the value of Oscillating
Gradient Diffusion Weighted Imaging (OGSE DWI) to gain
information about tumour radiation therapy response. 6
U87 glioblastoma bearing nude mice were separated into
an irradiated and control arm and examined with an
in-house developed cos-OGSE (f=200Hz) sequence in a
pre-clinical scanner. Resulting ADC maps were
statistically investigated and compared to corresponding
PGSE ADC maps. Average ADC values from OGSE DWI were
significantly higher in tumours than in normal tissue
and showed significant increase after radiation therapy.
ADC response to therapy in OGSE proved to be
significantly stronger and earlier than corresponding
PGSE ADCs.
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