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Abstract #2779

Cellular-level investigation of a diffusion time dependent contrast enhancement technique for oncological imaging

Jeremy J Flint 1,2 , Brian Hansen 3 , and Stephen J Blackband 1,4

1 Neuroscience, University of Florida, Gainesville, Florida, United States, 2 UF McKnight Brain Institute, Gainesville, Florida, United States, 3 Center for Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, 4 National High Magnetic Field Lab, Tallahassee, Florida, United States

Recent studies have reported a technique in which restriction spectrum imaging data is processed such that signal generated by the restricted water pool is isolated from that generated by the hindered pool. This method, purported to offer contrast sensitive to cell numbers, is presented as a useful tool for detecting the neoplastic proliferation of cells which occurs during tumor growth. We apply this technique to microimaging data collected in the CA1 region of the rat hippocampus. Our results support claims made regarding cellularity-based contrast as we report enhancement in the cell-dense stratum pyramidale which is not observed in adjacent laminae.

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