Cellular-level investigation of a diffusion time dependent contrast enhancement technique for oncological imaging
Jeremy J Flint 1,2 , Brian Hansen 3 , and Stephen J Blackband 1,4
Neuroscience, University of Florida,
Gainesville, Florida, United States,
McKnight Brain Institute, Gainesville, Florida, United
for Functionally Integrative Neuroscience, Aarhus
University, Aarhus, Denmark,
High Magnetic Field Lab, Tallahassee, Florida, United
Recent studies have reported a technique in which
restriction spectrum imaging data is processed such that
signal generated by the restricted water pool is
isolated from that generated by the hindered pool. This
method, purported to offer contrast sensitive to cell
numbers, is presented as a useful tool for detecting the
neoplastic proliferation of cells which occurs during
tumor growth. We apply this technique to microimaging
data collected in the CA1 region of the rat hippocampus.
Our results support claims made regarding
cellularity-based contrast as we report enhancement in
the cell-dense stratum pyramidale which is not observed
in adjacent laminae.
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