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Abstract #2803

Evidence of rotational dependency on standard DTI measurements

Arturo Cardenas-Blanco 1 , Julio Acosta-Cabronero 1 , Martin Kanowski 2 , Joern Kaufmann 2 , Claus Tempelman 2 , Stefan Teipel 3 , and Peter J Nestor 1

1 Brain plasticity and neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany, 2 Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany, 3 German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany

DTI has become a standard research tool to probe the structural organisation of neural tissue. Sub-optimal acquisitions or processing methodologies can, however, compromise the reliability of results. The aim of this study was to challenge the assumption that enabling 30 diffusion-encoding orientations would be sufficient for obtaining unbiased DTI measurements with standard methods. Results showed strong effects in DTI TBSS group analyses that were head-/FOV-positioning dependent; suggesting, therefore, that group studies with poor acquisition standardisation could lead to spurious results.

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