Abstract #2804
Reproducibility and Variation in Diffusion Measures of the In Vivo and Ex Vivo Squirrel Monkey Brain
Kurt Schilling 1 , Yurui Gao 1 , Iwona Stepniewska 2 , Ann S Choe 1 , Bennett A Landman 3 , and Adam W Anderson 1
1
VUIIS, Vanderbilt University, Nashville, TN,
United States,
2
Psychology,
Vanderbilt University, Nasvhille, United States,
3
Electrical
Engineering, Vanderbilt University, Nashville, TN,
United States
Here, we characterize the diffusion properties of the
squirrel monkey brain. We find the reproducibility of
the mean diffusivity, fractional anisotropy, and primary
eigenvector is comparable to that of human DTI studies,
establishing the validity of quantitative
cross-sectional and longitudinal DTI studies on the
squirrel monkey. Second, the relationship between in
vivo and ex vivo is considered. We confirm that death
and fixation causes significant changes to the tissue
microstructural properties that have a notable effect on
diffusion MRI, specifically a decreased mean diffusivity
and an increased fractional anisotropy. Finally, we
provide the normal values of diffusion indices in a
variety of both white and gray matter regions of
interest. This study serves as the basis for using the
squirrel monkey for diffusion MRI studies, supporting
the use of ex vivo DTI, as well as subsequent histology,
as a means of understanding image contrast seen on the
in vivo scans.
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