Detection of microstructural changes of nigra-striatum dopaminergic neurons in Parkinson's disease using high resolution DWI
Akira Nishikori 1,2 , Kohei Tsuruta 1,2 , Koji Kamagata 2 , Taku Hatano 2 , Fumi Okuzumi 2 , Masaaki Hori 2 , Michimasa Suzuki 2 , Shigeki Aoki 2 , and Atsushi Seno 1
Tokyo Metropolitan University, Arakawa-ku,
University School of Medicine, Bunkyo-ku, Tokyo, Japan
There are clinical proofs that the different clinical
subtypes of Parkinsonfs disease (PD) have a different
clinical course. Jellinger depicted a model of different
projections of nigral dopaminergic neurons to striatal
structures for the PD subtype. The purpose of our study
is to detect and clarify microstructural changes of
nigra-striatum dopaminergic neurons between akinetic-rigid
and tremor-dominant Parkinsonfs disease by using high
resolution diffusional kurtosis imaging (DKI) analysis.
Mean kurtosis value in the contralateral posterior
putamen were significantly higher in patients with
akinetic-rigid type than in patients with
tremor-dominant type, which is consistent with
neuropathological model were depicted by Jellinger.
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