Meeting Banner
Abstract #2832

Detection of microstructural changes of nigra-striatum dopaminergic neurons in Parkinson's disease using high resolution DWI

Akira Nishikori 1,2 , Kohei Tsuruta 1,2 , Koji Kamagata 2 , Taku Hatano 2 , Fumi Okuzumi 2 , Masaaki Hori 2 , Michimasa Suzuki 2 , Shigeki Aoki 2 , and Atsushi Seno 1

1 Tokyo Metropolitan University, Arakawa-ku, Tokyo, Japan, 2 Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan

There are clinical proofs that the different clinical subtypes of Parkinsonfs disease (PD) have a different clinical course. Jellinger depicted a model of different projections of nigral dopaminergic neurons to striatal structures for the PD subtype. The purpose of our study is to detect and clarify microstructural changes of nigra-striatum dopaminergic neurons between akinetic-rigid and tremor-dominant Parkinsonfs disease by using high resolution diffusional kurtosis imaging (DKI) analysis. Mean kurtosis value in the contralateral posterior putamen were significantly higher in patients with akinetic-rigid type than in patients with tremor-dominant type, which is consistent with neuropathological model were depicted by Jellinger.

This abstract and the presentation materials are available to members only; a login is required.

Join Here