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Abstract #2833

The Mean Kurtosis evaluation measurements show a considerable disparity from the analytically evaluated ones for a clinically used range of b-values

Andrey Chuhutin 1 , Ahmad Raza Khan 1 , Brian Hansen 1 , and Sune Nrhj Jespersen 1,2

1 Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark, 2 Dept. of Physics and Astronomy, Aarhus University, Denmark

As significant sensitivity of DKI to tissue pathologies was recently reported, this imaging modality is widely suspected to be useful for the neural tissue structure estimation. Being a Taylor expansion of the diffusion signal logarithm it deemed to have a validity region. We assessed the validity of the kurtosis evaluation versus for a range of b-values versus an analytically calculated ground truth based on the robust neurite model, that proved to finely describe the properties of the tissue. The results of the comparison show extremely high absolute error even for moderately small b-values both for extremely high and realistic SNR values.

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